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Volume 10 Issue 8 (August 2010)

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Volume 10 Issue 7 (July 2010)

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Volume 10 Issue 6 (June 2010)

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Volume 10 Issue 5 (May 2010)

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Volume 10 Issue 4 (April 2010)

 

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Volume 10 Issue 3 (March 2010)

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Volume 10 Issue 2 (February 2010)

In this issue, Guarrera et al report on a clinical trial of machine liver preservation. The system utilizes centrifugal flow via
the portal vein and hepatic artery at 3-7 _C.
See article by Guarrera et al on page 372–381.
Cover designed by Ken North of North Design Group.

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Volume 10 Issue 1 (January 2010)


 

Recipients of MHC-mismatched cardiac allografts were treated with a single dose of 500 _g anti-TNF_ mAb or rat IgG at
the time of transplant. A. The A/J allografts were retrieved from C57BL/6 recipients 9 and 12 hours post-transplant and
prepared frozen sections were stained to detect graft infiltrating neutrophils. B. Grafts were retrieved from groups of
4 recipients at the indicated times post-transplant and flow cytometry analyses of anti-CD45 and anti-Gr1 mAb stained
cells from digested grafts were performed to determine numbers of neutrophils infiltrating the allografts.
See article by Fairchild et al on page 59–68.
Cover designed by Ken North of North Design Group.

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Volume 9 Issue 12 (December 2009)

See randomized clinical trial results by Servais, et al on page 2552.

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Volume 9 Issue 11 (November 2009)

See randomized clinical trial results by Servais, et al on page 2552.
Cover Design by Ken North of North Design Group.
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Volume 9 Issue 10 (October 2009)   

 

See obituary by Terasaki on page 2441.
Photo Credit: Keystone/Stringer, Hulton Archive, Getty Images
Cover Design by Ken North of North Design Group
 

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 Volume 9 Issue 9 (September 2009)

Flow-cytometric analysis of peripheral blood mononuclear cells from healthy volunteers reveals that the CD4+ and CD8+ populations mount similar proliferative responses and contain comparable frequencies of alloreactive precursors.
See article by Macedo et al on page X.
 

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Volume 9 Issue 8 (August 2009)

Rat lung tissue post transplantation.
See article by Shilling and Wilkes on page1714.
 

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Volume 9 Issue 7 (July 2009)

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Volume 9 Issue 6 (June 2009)

Relationship between the total portal flow and graft regeneration.
See article by Cheng et al on page 1382.
Cover design by Ken North of the North Design Group.
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Volume 9 Issue 5 (May 2009)

Migration patterns of B2 lymphocytes. B2 lymphocytes begin life in the bone marrow, then migrate to either the gut, lymph nodes or spleen where they remain quiescent until they encounter antigen in the presence of antigen-presenting cells and T-helper cells. Following a series of steps, B cells may become terminally differentiated PCs. Some PCs may migrate back to the bone marrow where they may persist for years in specialized antiapoptotic ’survival niches‘.
Please see minireview by Stegall et al on page 998.
Cover design by Ken North of the North Design Group.
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Volume 9 Supplement (April 2009)

Mean five-year future lifetime by MELD
Average survival benefit from liver transplantation increases steadily as MELD increases. Benefit is defined as the difference between predicted years lived with a transplant versus without. See article by Schaubel et al on page 970.
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Volume 9 Issue 4 (April 2009)

Longitudinal analysis of EMT markers in bronchial brushing-derived epithelial cells. Epithelial cell expression of the EMT markers (_-sma and S100A4) and BAL cytokines (TGF_1 and HGF) were measured in a highly sensitized (pretransplant panel reactive antibody 90%) 57-year-female recipient of a single lung transplant for usual interstitial pneumonia (UIP). The patient developed treatment refractory BOS following a late episode of acute rejection (A2B0) at 6-month posttransplant and an episode of CMV pneumonitis at 10-month posttransplant. Note increased expression of EMT markers, TGF_1 and HGF concurrent with the diagnosis of BOS at 17 months after transplantation. No bronchial brushing samples were obtained at the last bronchoscopy at 20 months. _SMA = _-smooth muscle actin; S100A4; TGF_1 = transforming growth factor _; HGF = hepatocyte growth factor; FEV1 = forced expiratory volume in 1 second; BAL = bronchoalveolar lavage; CMV = cytomegalovirus.
Please see article by Hodge et al on pages 727–733.
Cover designed by Ken North of North Design Group.

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Volume 9 Issue 3 (March 2009)

 

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Volume 9 Issue 2 (February 2009)

Some potential regulatory and effector roles of NKG2D. Figure provided by Suárez-Álvarez et al (see article on pages 251–257) and designed by Ken North of north design group (Edmonton, Canada).
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Volume 9 Issue 1 (January 2009)

Figure provided by Djamali et al (see article on pages 74–82) and designed by Ken North of north design group (Edmonton, Canada).
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Volume 8 Supplement 2

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Volume 8 Issue 12 (December 2008)

Sarah, aged 1 year, died awaiting liver transplantation a few days after this photograph was taken by her mother. Her parents have since become vigorous activists for donation awareness in their community (reproduced with permission of K. Schonhoff).
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Volume 8 Issue 11 (November 2008)

Flow diagram of the process of UV-induced skin carcinoma, and the interference from the immunosuppressive drugs, azathioprine (Aza), cyclosporine (CS) and Rapamycin (Rapa).
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Volume 8 Issue 10 (October 2008)

Novel biologics and small molecules targeting cell surface receptors and intracellular pathways of the T cell. PKC = Protein Kinase C, CN = Calcineurin Inhibitor.
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Volume 8 Issue 9 (September 2008)

Left figure:
Shown is the cumulative survival of all heart transplant recipients at Stanford University over the 40-year period between 1968 and 2007, broken down into 5-year intervals. The cumulative survival continuously improved with every successive 5-year period. Sixty out of 479 patients transplanted before 1988 survived at least 20 years (grey box). The conditional half-life in this patient population was 28.1 years. See article by Deuse et al on pages 1769–1774.
Right figure:
Cytochrome c immunostaining was performed after transplantation of wildtype (JNK2 +/+) and JNK2 deficient (JNK2 -/-) mouse livers after 30 h of cold storage. In JNK2 +/+ grafts, brown immunostaining for cytochrome c was diffuse, indicating cytochrome c release from mitochondria to the cytosol due to the mitochondrial permeability transition. In JNK2 -/- grafts, cytochrome c immunostaining was punctate, indicating mitochondrial retention of cytochrome c. Bar is 20 μm.
See article by Theruvath et al on pages 1819–1828.
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 Volume 8 Issue 8 (August 2009)

Figure on the left-hand side:
Digital images from the electron microscopy of transplant glomerulopathy and peritubular capillary laminations.
A: Glomerular loop with new basement membrane (arrow), i.e., duplication, activated endothelium (arrow) and lumen with a red blood cell (RBC, arrow). Original magnification 7100x.
B: Glomerular loop with thickened basement membrane laminations (arrow), and activated endothelium (arrow). Podocytes for reference (arrow). Original magnification, 15000x.
C: Peritubular capillary with laminations (arrow) and activated endothelium (arrow). Peritubular capillary lumen for reference (PTC Lumen). Original magnification, 9100x. See article by Smith et al on pages 1662–1672.
Figure on the right-hand side:
ECD in Canada defined as donors ≥60 years of age. In the United States, Expanded criteria donors (ECD) are donors age ≥60 years or donors aged 50–59 years with at least two of the following conditions: cerebrovascualar accident as cause of death, serum creatinine > 1.5 mg/dl or a history of hypertension. * 2007 Canadian data are preliminary and have not been verified. The number of SCD, ECD and DCD in the United States were obtained from reference 10 within the article by Gill et al on pages 1580–1587.
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Volume 8 Issue 7 (July 2008)

Figure 1. Immunohistochemistry for CCR1, CCR2 and CCR5 on lung allograft biopsy tissue with CMV disease, showing (A) type II pneumocytes (red arrows) and (B) alveolar macrophages (AM). Pulmonary CMVD biopsy specimen showing CCR1 expression predominantly by C) AM (green arrows), other mononuclear cells (blue arrows) and D) interstitial mast cells (orange arrows). Pulmonary CMVD biopsy specimen showing CCR5 localization to E) AM (green arrows), interstitial mast cells (orange arrows) and F) other mononuclear cells (blue arrows). All images were photographed at 400 x original magnication.
Figure 2a. Acute Rejection. Erythematous macules on the sentinel skin graft at day 20 post partial face transplantation. Clinical involvement of >50% of the composite tissue graft.
Figure 2b. Regression of signs of skin rejection of the sentinel skin graft after increasing the immunossuppressive treatment.
Figure 2c. Banff 2007 Classification of Skin-Containing Composite Tissue Allograft Pathology Grade I rejection of the sentinel skin graft.
Figure 2d. Pathological appearance of the sentinel skin graft after increasing the immunosuppressive regimen.
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Volume 8 Issue 6 (June 2008)

Figure 1. Acute T-cell mediated pancreas allograft rejection 5 years post transplantation, triggered by decreased immunosuppression due to refractory viral infections. Two representative fields of the needle core biopsy demonstrate lymphocytic inflammatory infiltrates involving the glandular tissue, interstitium and vessels. CD8 stain highlights endothelial inflammation in an artery and a vein (center lower picture) and amidst the acinar cells (lower right). Asterisk in top left
image marks active transplant arteriopathy (arterial intimal fibrosis with mononuclear inflammation), also indicative of ongoing T-cell mediated rejection. Please see article by Drachenberg et al on page 1237.
Figure 2. (A) Overall survival after primary liver transplantation (n=147) vs. liver resection in patients potentially eligible for LT (n=80); (B) Disease-free survival after primary LT (n=147) vs. LR in patients potentially eligible for LT (n=80). Please see article by Del Gaudio et al on page 1177.
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Volume 8 Issue 5 (May 2008)

Figure 1. Double-immunofluorescent immunohistochemistry of infiltrating CD3+ T-cells in CAV vessels. For a full description see Figure 4 in Hagemeijer et al in this issue on page 1040.
Figure 2. In this figure, Shimazono (2007) illustrates four modes of transplant tourism. Mode 1 entails a recipient traveling from Country B to Country A where the donor and transplant center are located, Mode 2 entails a donor from Country A traveling to Country B where the recipient and transplant center are located, Mode 3 entails a donor and recipient from Country A traveling to Country B where the transplant center is located, and Mode 4 entails a donor from Country A and a recipient from Country B traveling to Country C where the transplant center is located. Reproduced with permission from Yosuke Shimazono, University of Oxford Institute of Social and Cultural Anthropology.
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Volume 8 Supplement 1 (April 2008)

 

Front cover: These six graphs provide a quick view of transplant and waiting list activity in the United States over the past decade. (Multi-organ transplants are excluded.) Additional detail is given in the organ-specific articles of this report, as well as in the overview article by Port et al.

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Volume 8 Issue 4 (April 2008)

The collage depicting the watchful eye symbolizes the vigilance that, on many different levels, monitors organ transplantation in the United States.
Cover Illustration by Andrew Swartz.
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Volume 8 Issue 3 (March 2008)

Figure 1: Graft survival of MHC-mismatched A/J renal allografts in wild type C57BL/6 vs. B6.CCR5-/- recipients. Groups of wild type C57BL/6 (- -, n=8) and B6.CCR5-/- (-♦-, n=7) received renal allografts from A/J donors and graft survival was followed by daily examination of overall animal health and weekly serum creatinine checks. Allograft rejection was confirmed by histopathology.
Figure 2: Left: Characteristic glomerular features of TG, note extensive duplication of GBM (arrows); Right: TG is often a focal lesion affecting only some glomeruli (top but not the bottom glomerulus in this slide). By Banff criteria (17), the diagnosis of TG is based on the identification of duplicated GBM in more than 10% of glomerular capillary loops in the most affected non-sclerotic glomerulus.
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Volume 8 Issue 2 (February 2008)

Top panel: Cumulative incidence of biopsy-proven acute rejection (BPAR) in patients randomized to steroid-free therapy, steroid withdrawal at Day 7, or standard steroids (Kaplan-Meier, ITT population). P=0.003 for the steroid-free group and p=0.03 for the steroid-withdrawal group, both versus the standard-steroids group (log rank test).
Bottom panel: A group of children who received heart transplants as infants at a picnic in June 2007 in Toronto, Ontario, Canada. Picture taken by Dr. Anne Dipchand and used with her permission and consent of the families involved.
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Volume 8 Issue 1 (January 2008)

This figure illustrates the overall process from bone marrow aspiration to the performance of the allo-ASC functional assays. The pie chart demonstrates the percentages of each cell type in the CD 138* fraction of cells. Please see article by D.K. Perry et al in this issue on page 133. (The top panel of this figure was reproduced with permission from the Mayo Foundation for Medical Education and Research.)
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Volume 7 Issue 12 (December 2007)

Relationship between PBT scores, histopathologic lesions, histopathologic and clinical diagnosis, and classifier predictions. A) Biopsies for cause (n = 143) were sorted based on the CAT1 score (from lowest to highest). According to this order, scores for all PBTs (CAT1, CAT2, GRIT1, GRIT2, KT1, KT2) are illustrated for each individual biopsy for cause. The panel above the graph illustrates the relationship of the PBT scores to the presence of Acute Tubular Necrosis (ATN), the degree of interstitial infiltrate (i score), tubulitis (t score), intimal arteritis (v score), histopathology diagnosis, retrospective clinical-pathologic diagnosis, and the probability of rejection (%), predicted from the classifiers. Please see article by Mueller & Einecke et al on page 2712 of this issue.
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 Volume 7 Issue 11 (November 2007)

 

Platelets in action: Totally granular, dude!

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Volume 7 Issue 10 (October 2007)

 

Left image: Time to (A) acute humoral and (B) cellular rejection in living donor renal transplant recipients
Right image: Incidence of de novo antibodies after islet transplantation
 

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Volume 7 Issue 9 (September 2007)

 

Left image: C4D staining of capillaries (top) and capillary endothelial swelling and leukocyte margination (bottom) in antibody-mediated heart transplant rejection
Right image: Reduction in CMV viral load with time in patients treated with oral valganciclovir and intravenous valganciclovir
 

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Volume 7 Issue 8 (August 2007)

 

Left image: Dr. Olga Jonasson the first woman transplant surgeon 1934-2006
Right image: Global expression of PV1 in the glomerulus of transplant glomerulopathy
 

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Volume 7 Issue 7 (July 2007)

 

‘The first successful organ transplant’ Joel Babb

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Volume 7 Issue 6 (June 2007)

 

 

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Volume 7 Issue 5 (May 2007)

Left image: New additions to the deceased donor renal transplant waiting list 2000-2005
Right image: Mouse cardiac allograft survival in wild-type and B3 integrin-deficient recipients
 

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 Volume 7 Issue 4 (April 2007)

 

Left image: Conditional gene expression: a new tool for the transplantologist
Right image: Estimated glomerular filtration rates underestimate graph functional loss in kidney transplants
 

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Volume 7 Issue 3 (March 2007)

 

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Volume 7 Issue 2 (February 2007)

Persistent inflammation in renal allografts detected by protocol biopsies

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Volume 7 Issue 1 (January 2007)

Left image: Paying tribute to Dr. Robert Zhong 1946-2006
Right image: Loss in renal function after clinical islet transplantation
 

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Volume 6 Issue 12 (December 2006)

 

Current Issues in Lung Transplantation

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Volume 6 Issue 11 (November 2006)

Left image: CATHETER SUBTRACTION ANGIOGRAPHY OF A HEPATOCELLULAR CARCINOMA
Right image: RECURRENT IgA NEPHROPATHY AFTER RENAL TRANSPLANT
 

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Volume 6 Issue 10 (October 2006)

Emory Algorithm for evaluating the sensitized patient

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Volume 6 Issue 9 (September 2009)

Left image: BK virus DNA in several tubular epithelial cells
Right image: Decline in glomerular filtration rate after kidney transplant
 

 

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Volume 6 Issue 8 (August 2006)

 

Emerging issues and insights in antibody-mediated rejection

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Volume 6 Issue 7 (July 2006)

 

PANDEMIC INFLUENZA AND ITS IMPLICATIONS FOR TRANSPLANTATION
 

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Volume 6 Issue 6 (June 2006)

 

CARDIAC ALLOGRAFT VASCULOPATHY INITIATED AND PROPAGATED BY IMMUNOLOGIC AND NON-IMMUNOLOGIC FACTORS
 

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Volume 6 Issue 5 (May 2006)


 

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Volume 6 Issue 4 (April 2006)

 

Left Image: Bilateral hand transplantation: five years later
Right Image: Late kidney deterioration in two of ten patients with “operational tolerance”

 

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Volume 6 Issue 3 (March 2006)

 

Intravenous immunoglobulin (ivig) blocks cytotoxic anti-HLA antibodies in the panel reactive antibody system
 

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Volume 6 Issue 2 (February 2006)

 

Left Image: C4d staining of interacinar capillaries in a pancreas transplant with antibody-mediated rejection (top) versus control (bottom)
Right Image: Risk adjusted cumulative sum chart depicts renal transplant center with a cluster of graft failures

 

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Volume 6 Issue 1 (January 2006)

 

Top image: Liver ischemia after intraportal islet transplantation: necrosis on liver surface (left) intraportal islet cluster with necrotic hepatic tissue (right)
Bottom image: Laryngeal replantation technique in a human

 

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Volume 1 Issue 2 (July 2001)

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Volume 1 Issue 1 (May 2001)

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